Ontology highlight
ABSTRACT:
SUBMITTER: Dutta P
PROVIDER: S-EPMC3401326 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Dutta Partha P Courties Gabriel G Wei Ying Y Leuschner Florian F Gorbatov Rostic R Robbins Clinton S CS Iwamoto Yoshiko Y Thompson Brian B Carlson Alicia L AL Heidt Timo T Majmudar Maulik D MD Lasitschka Felix F Etzrodt Martin M Waterman Peter P Waring Michael T MT Chicoine Adam T AT van der Laan Anja M AM Niessen Hans W M HW Piek Jan J JJ Rubin Barry B BB Butany Jagdish J Stone James R JR Katus Hugo A HA Murphy Sabina A SA Morrow David A DA Sabatine Marc S MS Vinegoni Claudio C Moskowitz Michael A MA Pittet Mikael J MJ Libby Peter P Lin Charles P CP Swirski Filip K FK Weissleder Ralph R Nahrendorf Matthias M
Nature 20120701 7407
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons. Here we show that the systemic response to ischaemic injury aggravates chronic atherosclerosis. After myocardial infarction or stroke, Apoe-/- mice developed larger atherosclerotic lesions with a more advanced morphology. Th ...[more]