Ontology highlight
ABSTRACT:
SUBMITTER: Khoronenkova SV
PROVIDER: S-EPMC3401373 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Khoronenkova Svetlana V SV Dianova Irina I II Ternette Nicola N Kessler Benedikt M BM Parsons Jason L JL Dianov Grigory L GL
Molecular cell 20120221 6
The deubiquitylation enzyme USP7/HAUSP plays a major role in regulating genome stability and cancer prevention by controlling the key proteins involved in the DNA damage response. Despite this important role in controlling other proteins, USP7 itself has not been recognized as a target for regulation. Here, we report that USP7 regulation plays a central role in DNA damage signal transmission. We find that stabilization of Mdm2, and correspondingly p53 downregulation in unstressed cells, is accom ...[more]