Ontology highlight
ABSTRACT:
SUBMITTER: Lundberg LE
PROVIDER: S-EPMC3401434 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Lundberg Lina E LE Figueiredo Margarida L A ML Stenberg Per P Larsson Jan J
Nucleic acids research 20120319 13
Variation in the number of individual chromosomes (chromosomal aneuploidy) or chromosome segments (segmental aneuploidy) is associated with developmental abnormalities and reduced fitness in all species examined; it is the leading cause of miscarriages and mental retardation and a hallmark of cancer. However, despite their documented importance in disease, the effects of aneuploidies on the transcriptome remain largely unknown. We have examined the expression effects of seven heterozygous chromo ...[more]