Ontology highlight
ABSTRACT:
SUBMITTER: Bonisch C
PROVIDER: S-EPMC3401452 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Bönisch Clemens C Schneider Katrin K Pünzeler Sebastian S Wiedemann Sonja M SM Bielmeier Christina C Bocola Marco M Eberl H Christian HC Kuegel Wolfgang W Neumann Jürgen J Kremmer Elisabeth E Leonhardt Heinrich H Mann Matthias M Michaelis Jens J Schermelleh Lothar L Hake Sandra B SB
Nucleic acids research 20120329 13
The histone variant H2A.Z has been implicated in many biological processes, such as gene regulation and genome stability. Here, we present the identification of H2A.Z.2.2 (Z.2.2), a novel alternatively spliced variant of histone H2A.Z and provide a comprehensive characterization of its expression and chromatin incorporation properties. Z.2.2 mRNA is found in all human cell lines and tissues with highest levels in brain. We show the proper splicing and in vivo existence of this variant protein in ...[more]