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ABSTRACT: Objective
To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk.Research design and methods
Korean subjects (n = 7,233; 40-79 years old) who were not diagnosed with diabetes at baseline were enrolled through the National Health Insurance Corporation. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week) without dietary advice.Results
During follow-up (mean = 2 years), there were 303 incidents of type 2 diabetes in the nonexercise program group (n = 5,286) and 83 in the exercise program group (n = 1,947). After adjusting for confounders, the risk of type 2 diabetes was positively associated with BMI and inversely with regular exercise, especially among overweight/obese subjects. After further adjustment for BMI, the odds ratios for risk of diabetes associated without and with regular exercise were 1.00 and 0.77, respectively. Among subjects with normal fasting glucose, exercise reduced the diabetes risk; however, among those with impaired fasting glucose (IFG), the protective effect of exercise was found only among overweight/obese subjects. The overweight/obese subjects in the exercise program group exhibited improved fasting glucose compared with the nonexercise program group and showed 1.5 kg of weight loss and a 3-cm decrease in waist circumference. Among overweight/obese subjects with unchanged fasting glucose, weight loss was greater in the exercise program group.Conclusions
Regular exercise reduces the risk of type 2 diabetes in overweight/obese individuals. Particularly, regular exercise and weight or waist circumference control are critical factors for preventing diabetes in overweight/obese individuals with IFG.
SUBMITTER: Chae JS
PROVIDER: S-EPMC3402273 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Chae Jey Sook JS Kang Ryungwoo R Kwak Jung Hyun JH Paik Jean Kyung JK Kim Oh Yoen OY Kim Minjoo M Park Ji Won JW Jeon Justin Y JY Lee Jong Ho JH
Diabetes care 20120611 8
<h4>Objective</h4>To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk.<h4>Research design and methods</h4>Korean subjects (n = 7,233; 40-79 years old) who were not diagnosed with diabetes at baseline were enrolled through the National Health Insurance Corporation. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week ...[more]