Ontology highlight
ABSTRACT:
SUBMITTER: Fels J
PROVIDER: S-EPMC3402397 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Fels Johannes J Jeggle Pia P Kusche-Vihrog Kristina K Oberleithner Hans H
PloS one 20120723 7
The release of the main vasodilator nitric oxide (NO) by the endothelial NO synthase (eNOS) is a hallmark of endothelial function. We aim at elucidating the underlying mechanism how eNOS activity depends on cortical stiffness (К(cortex)) of living endothelial cells. It is hypothesized that cortical actin dynamics determines К(cortex) and directly influences eNOS activity. By combined atomic force microscopy and fluorescence imaging we generated mechanical and optical sections of single living ce ...[more]