Ontology highlight
ABSTRACT:
SUBMITTER: Lahtinen AM
PROVIDER: S-EPMC3402479 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lahtinen Annukka M AM Noseworthy Peter A PA Havulinna Aki S AS Jula Antti A Karhunen Pekka J PJ Kettunen Johannes J Perola Markus M Kontula Kimmo K Newton-Cheh Christopher C Salomaa Veikko V
PloS one 20120723 7
<h4>Background</h4>Sudden cardiac death (SCD) accounts for up to half of cardiac mortality. The risk of SCD is heritable but the underlying genetic variants are largely unknown. We investigated whether common genetic variants predisposing to arrhythmia or related electrocardiographic phenotypes, including QT-interval prolongation, are associated with increased risk of SCD.<h4>Methodology/principal findings</h4>We studied the association between 28 candidate SNPs and SCD in a meta-analysis of fou ...[more]