Dataset Information
Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
Ontology highlight
ABSTRACT: Background
Auditory verbal hallucinations (AVH), a prominent symptom of schizophrenia, are often highly distressing for patients. Better understanding of the pathogenesis of hallucinations could increase therapeutic options. Magnetoencephalography (MEG) provides direct measures of neuronal activity and has an excellent temporal resolution, offering a unique opportunity to study AVH pathophysiology.Methods
Twelve patients (10 paranoid schizophrenia, 2 psychosis not otherwise specified) indicated the presence of AVH by button-press while lying in a MEG scanner. As a control condition, patients performed a self-paced button-press task. AVH-state and non-AVH state were contrasted in a region-of-interest (ROI) approach. In addition, the two seconds before AVH onset were contrasted with the two seconds after AVH onset to elucidate a possible triggering mechanism.Results
AVH correlated with a decrease in beta-band power in the left temporal cortex. A decrease in alpha-band power was observed in the right inferior frontal gyrus. AVH onset was related to a decrease in theta-band power in the right hippocampus.Conclusions
These results suggest that AVH are triggered by a short aberration in the theta band in a memory-related structure, followed by activity in language areas accompanying the experience of AVH itself.
SUBMITTER: van Lutterveld R
PROVIDER: S-EPMC3402538 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
PloS one 20120723 7
<h4>Background</h4>Auditory verbal hallucinations (AVH), a prominent symptom of schizophrenia, are often highly distressing for patients. Better understanding of the pathogenesis of hallucinations could increase therapeutic options. Magnetoencephalography (MEG) provides direct measures of neuronal activity and has an excellent temporal resolution, offering a unique opportunity to study AVH pathophysiology.<h4>Methods</h4>Twelve patients (10 paranoid schizophrenia, 2 psychosis not otherwise speci ...[more]