Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC3402601 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wu Jun J Boström Pontus P Sparks Lauren M LM Ye Li L Choi Jang Hyun JH Giang An-Hoa AH Khandekar Melin M Virtanen Kirsi A KA Nuutila Pirjo P Schaart Gert G Huang Kexin K Tu Hua H van Marken Lichtenbelt Wouter D WD Hoeks Joris J Enerbäck Sven S Schrauwen Patrick P Spiegelman Bruce M BM
Cell 20120712 2
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical ...[more]