Ontology highlight
ABSTRACT:
SUBMITTER: Chang JT
PROVIDER: S-EPMC3402628 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Chang Jessica T JT Lowery Laura Anne LA Lowery Laura Anne LA Sive Hazel H
Developmental biology 20120607 2
Formation of the vertebrate brain ventricles requires both production of cerebrospinal fluid (CSF), and its retention in the ventricles. The Na,K-ATPase is required for brain ventricle development, and we show here that this protein complex impacts three associated processes. The first requires both the alpha subunit (Atp1a1) and the regulatory subunit, Fxyd1, and leads to formation of a cohesive neuroepithelium, with continuous apical junctions. The second process leads to modulation of neuroep ...[more]