Ontology highlight
ABSTRACT:
SUBMITTER: Burgess J
PROVIDER: S-EPMC3403109 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Burgess Jason J Del Bel Lauren M LM Ma Cheng-I J CI Barylko Barbara B Polevoy Gordon G Rollins Janet J Albanesi Joseph P JP Krämer Helmut H Brill Julie A JA
Development (Cambridge, England) 20120712 16
Type II phosphatidylinositol 4-kinase (PI4KII) produces the lipid phosphatidylinositol 4-phosphate (PI4P), a key regulator of membrane trafficking. Here, we generated genetic models of the sole Drosophila melanogaster PI4KII gene. A specific requirement for PI4KII emerged in larval salivary glands. In PI4KII mutants, mucin-containing glue granules failed to reach normal size, with glue protein aberrantly accumulating in enlarged Rab7-positive late endosomes. Presence of PI4KII at the Golgi and o ...[more]