Ontology highlight
ABSTRACT:
SUBMITTER: Skinner JJ
PROVIDER: S-EPMC3403437 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Skinner John J JJ Lim Woon K WK Bédard Sabrina S Black Ben E BE Englander S Walter SW
Protein science : a publication of the Protein Society 20120611 7
To examine the relationship between protein structural dynamics and measurable hydrogen exchange (HX) data, the detailed exchange behavior of most of the backbone amide hydrogens of Staphylococcal nuclease was compared with that of their neighbors, with their structural environment, and with other information. Results show that H-bonded hydrogens are protected from exchange, with HX rate effectively zero, even when they are directly adjacent to solvent. The transition to exchange competence requ ...[more]