Genome wide assessment of young onset Parkinson's disease from Finland.
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ABSTRACT:
SUBMITTER: Hernandez DG
PROVIDER: S-EPMC3404082 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Genome wide assessment of young onset Parkinson's disease from Finland.
Hernandez Dena G DG Nalls Michael A MA Ylikotila Pauli P Keller Margaux M Hardy John A JA Majamaa Kari K Singleton Andrew B AB
PloS one 20120724 7
In the current study we undertook a series of experiments to test the hypothesis that a monogenic cause of disease may be detectable within a cohort of Finnish young onset Parkinson's disease patients. In the first instance we performed standard genome wide association analyses, and subsequent risk profile analysis. In addition we performed a series of analyses that involved testing measures of global relatedness within the cases compared to controls, searching for excess homozygosity in the cas ...[more]
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