Ontology highlight
ABSTRACT:
SUBMITTER: Findeisen M
PROVIDER: S-EPMC3404467 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Findeisen Maria M Würker Cäcilia C Rathmann Daniel D Meier René R Meiler Jens J Olsson Roger R Beck-Sickinger Annette G AG
Journal of medicinal chemistry 20120626 13
The binding pocket of both NPFF receptors was investigated, focusing on subtype-selective behavior. By use of four nonpeptidic compounds and the peptide mimetics RF9 and BIBP3226, agonistic and antagonistic properties were characterized. A set of Ala receptor mutants was generated. The binding pocket was narrowed down to the upper part of transmembrane helices V, VI, VII and the extracellular loop 2. Positions 5.27 and 6.59 have been shown to have a strong impact on receptor activation and were ...[more]