A1/Bfl-1 in leukocyte development and cell death.
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ABSTRACT:
SUBMITTER: Ottina E
PROVIDER: S-EPMC3405526 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
A1/Bfl-1 in leukocyte development and cell death.
Ottina Eleonora E Tischner Denise D Herold Marco J MJ Villunger Andreas A
Experimental cell research 20120204 11
The function of the anti-apoptotic Bcl-2 family member Bcl2a1/Bfl-1/A1 is poorly understood due to the lack of appropriate loss-of-function mouse models and redundant effects with other Bcl-2 pro-survival proteins upon overexpression. Expression analysis of A1 suggests predominant roles in leukocyte development, their survival upon viral or bacterial infection, as well as during allergic reactions. In addition, A1 has been implicated in autoimmunity and the pathology and therapy resistance of he ...[more]
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