Unknown

Dataset Information

0

IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.


ABSTRACT: IL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and clinical and experimental data indicate that disease progression is associated with expanded numbers of CD4⁺ IFNγ⁺ T cells committed to IL-10 production. Here, combining conditional cell-specific depletion with adoptive transfer, we demonstrate that only conventional CD11c(hi) DCs that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo. In contrast, CD11c(hi) as well as CD11c(int/lo) cells isolated from infected mice were capable of reversing the host protective effect of diphtheria toxin-mediated CD11c⁺ cell depletion. This was reflected by increased splenomegaly, inhibition of NO production and increased parasite burden. Thus during chronic infection, multiple CD11c⁺ cell populations can actively suppress host resistance and enhance immunopathology, through mechanisms that do not necessarily involve IL-10-producing Th1 cells.

SUBMITTER: Owens BM 

PROVIDER: S-EPMC3406093 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7646755 | biostudies-literature
| S-EPMC3990611 | biostudies-literature
| S-EPMC4411907 | biostudies-other
| S-EPMC6299163 | biostudies-literature
| S-EPMC2118728 | biostudies-literature
| S-EPMC5595963 | biostudies-literature
| S-EPMC4868652 | biostudies-literature
| S-EPMC4151203 | biostudies-literature
| S-EPMC5823892 | biostudies-literature
| S-EPMC3608091 | biostudies-literature