Ontology highlight
ABSTRACT:
SUBMITTER: Antoon JW
PROVIDER: S-EPMC3406343 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Antoon James W JW Lai Rongye R Struckhoff Amanda P AP Nitschke Ashley M AM Elliott Steven S Martin Elizabeth C EC Rhodes Lyndsay V LV Yoon Nam Seung NS Salvo Virgilio A VA Shan Bin B Beckman Barbara S BS Nephew Kenneth P KP Burow Matthew E ME
Scientific reports 20120727
Altered death receptor signaling and resistance to subsequent apoptosis is an important clinical resistance mechanism. Here, we investigated the role of death receptor resistance in breast cancer progression. Resistance of the estrogen receptor alpha (ER)-positive, chemosensitive MCF7 breast cancer cell line to tumor necrosis factor (TNF) was associated with loss of ER expression and a multi-drug resistant phenotype. Changes in three major pathways were involved in this transition to a multidrug ...[more]