Ontology highlight
ABSTRACT:
SUBMITTER: Dubrovskyi O
PROVIDER: S-EPMC3407333 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Dubrovskyi Oleksii O Tian Xinyong X Poroyko Valeriy V Yakubov Bakhtiyor B Birukova Anna A AA Birukov Konstantin G KG
FEBS letters 20120620 16
Barrier-protective agonists induce association of focal adhesions (FA) and adherens junctions (AJ) in endothelial cells. Here we identified specific domains of FA protein paxillin interacting with AJ protein and examined regulation of paxillin domain interactions with β-catenin by Rac GTPase. Co-expression of paxillin LD-1,2; LD-3,4; LIM-1,2; and LIM-3,4 domains with β-catenin showed exclusive interaction of LIM-1,2 and LIM-3,4 with β-catenin, which was enhanced by agonist-induced Rac activation ...[more]