Ontology highlight
ABSTRACT:
SUBMITTER: Raina M
PROVIDER: S-EPMC3407334 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Raina Medha M Elgamal Sara S Santangelo Thomas J TJ Ibba Michael M
FEBS letters 20120607 16
In archaea and eukaryotes aminoacyl-tRNA synthetases (aaRSs) associate in multi-synthetase complexes (MSCs), however the role of such MSCs in translation is unknown. MSC function was investigated in vivo in the archaeon Thermococcus kodakarensis, wherein six aaRSs were affinity co-purified together with several other factors involved in protein synthesis, suggesting that MSCs may interact directly with translating ribosomes. In support of this hypothesis, the aminoacyl-tRNA synthetase (aaRS) act ...[more]