Ontology highlight
ABSTRACT:
SUBMITTER: Dagon Y
PROVIDER: S-EPMC3407689 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Dagon Yossi Y Hur Elizabeth E Zheng Bin B Wellenstein Kerry K Cantley Lewis C LC Kahn Barbara B BB
Cell metabolism 20120621 1
The PI3K-AKT, mTOR-p70S6 kinase and AMPK pathways play distinct and critical roles in metabolic regulation. Each pathway is necessary for leptin's anorexigenic effects in the hypothalamus. Here we show that these pathways converge in an integrated phosphorylation cascade to mediate leptin action in the hypothalamus. We identify serine(491) on α2AMPK as the site of convergence and show that p70S6 kinase forms a complex with α2AMPK, resulting in phosphorylation on serine(491). Blocking α2AMPK-seri ...[more]