Suppression of erythroid development in vitro by Plasmodium vivax.

ABSTRACT:

Background

Severe anaemia due to dyserythropoiesis has been documented in patients infected with Plasmodium vivax, however the mechanism responsible for anaemia in vivax malaria is poorly understood. In order to better understand the role of P. vivax infection in anaemia the inhibition of erythropoiesis using haematopoietic stem cells was investigated.

Methods

Haematopoietic stem cells/CD34+ cells, isolated from normal human cord blood were used to generate growing erythroid cells. Exposure of CD34+ cells and growing erythroid cells to P. vivax parasites either from intact or lysed infected erythrocytes (IE) was examined for the effect on inhibition of cell development compared with untreated controls.

Results

Both lysed and intact infected erythrocytes significantly

SUBMITTER: Panichakul T 

PROVIDER: S-EPMC3407695 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature