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Formamido-diterpenes from the South China Sea sponge Acanthella cavernosa.

ABSTRACT: Seven new formamido-diterpenes, cavernenes A-D (1-4), kalihinenes E and F (5-6), and kalihipyran C (7), together with five known compounds (8-12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC(50) values in the range of 6-18 μM. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 μg/mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, Cryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 μg/mL, respectively.

SUBMITTER: Xu Y

PROVIDER: S-EPMC3407923 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Formamido-diterpenes from the South China Sea sponge Acanthella cavernosa.

Xu Ying Y Lang Jun-Hui JH Jiao Wei-Hua WH Wang Ru-Ping RP Peng Ying Y Song Shao-Jiang SJ Zhang Bao-Hua BH Lin Hou-Wen HW

Marine drugs 20120702 7

Seven new formamido-diterpenes, cavernenes A-D (1-4), kalihinenes E and F (5-6), and kalihipyran C (7), together with five known compounds (8-12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC(50) values in the ...[more]

PMID: 22851918

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