Ontology highlight
ABSTRACT:
SUBMITTER: Hatzistergos KE
PROVIDER: S-EPMC3408082 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Hatzistergos Konstantinos E KE Quevedo Henry H Oskouei Behzad N BN Hu Qinghua Q Feigenbaum Gary S GS Margitich Irene S IS Mazhari Ramesh R Boyle Andrew J AJ Zambrano Juan P JP Rodriguez Jose E JE Dulce Raul R Pattany Pradip M PM Valdes David D Revilla Concepcion C Heldman Alan W AW McNiece Ian I Hare Joshua M JM
Circulation research 20100729 7
<h4>Rationale</h4>The regenerative potential of the heart is insufficient to fully restore functioning myocardium after injury, motivating the quest for a cell-based replacement strategy. Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into cardiac myocytes.<h4>Objective</h4>Here, we test the hypothesis that bone marrow derived MSCs stimulate the proliferation and differentiation of endogenous cardia ...[more]