Ontology highlight
ABSTRACT:
SUBMITTER: Passet B
PROVIDER: S-EPMC3408428 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Passet Bruno B Young Rachel R Makhzami Samira S Vilotte Marthe M Jaffrezic Florence F Halliez Sophie S Bouet Stéphan S Marthey Sylvain S Khalifé Manal M Kanellopoulos-Langevin Colette C Béringue Vincent V Le Provost Fabienne F Laude Hubert H Vilotte Jean-Luc JL
PloS one 20120730 7
The potential requirement of either the Prion or Shadoo protein for early mouse embryogenesis was recently suggested. However, the current data did not allow to precise the developmental process that was affected in the absence of both proteins and that led to the observed early lethal phenotype. In the present study, using various Prnp transgenic mouse lines and lentiviral vectors expressing shRNAs that target the Shadoo-encoding mRNA, we further demonstrate the specific requirement of at least ...[more]