Ontology highlight
ABSTRACT:
SUBMITTER: Polosukhina A
PROVIDER: S-EPMC3408583 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Neuron 20120701 2
Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are degenerative blinding diseases caused by the death of rods and cones, leaving the remainder of the visual system intact but largely unable to respond to light. Here, we show that AAQ, a synthetic small molecule photoswitch, can restore light sensitivity to the retina and behavioral responses in vivo in mouse models of RP, without exogenous gene delivery. Brief application of AAQ bestows prolonged light sensitivity on multip ...[more]