Ontology highlight
ABSTRACT:
SUBMITTER: Zhou B
PROVIDER: S-EPMC3408618 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Zhou Bing B Cai Qian Q Xie Yuxiang Y Sheng Zu-Hang ZH
Cell reports 20120712 1
Neurotrophin signaling is crucial for neuron growth. While the "signaling endosomes" hypothesis is one of the accepted models, the molecular machinery that drives retrograde axonal transport of TrkB signaling endosomes is largely unknown. In particular, mechanisms recruiting dynein to TrkB signaling endosomes have not been elucidated. Here, using snapin deficient mice and gene rescue experiments combined with compartmentalized cultures of live cortical neurons, we reveal that Snapin, as a dynein ...[more]