Ontology highlight
ABSTRACT:
SUBMITTER: Weinberger L
PROVIDER: S-EPMC3408861 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Weinberger Leehee L Voichek Yoav Y Tirosh Itay I Hornung Gil G Amit Ido I Barkai Naama N
Molecular cell 20120607 2
Gene expression shows a significant variation (noise) between genetically identical cells. Noise depends on the gene expression process regulated by the chromatin environment. We screened for chromatin factors that modulate noise in S. cerevisiae and analyzed the results using a theoretical model that infers regulatory mechanisms from the noise versus mean relationship. Distinct activities of the Rpd3(L) and Set3 histone deacetylase complexes were predicted. Both HDACs repressed expression. Yet, ...[more]