Ontology highlight
ABSTRACT:
SUBMITTER: Friggeri A
PROVIDER: S-EPMC3409281 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Friggeri Arnaud A Banerjee Sami S Xie Na N Cui Huachun H De Freitas Andressa A Zerfaoui Mourad M Dupont Hervé H Abraham Edward E Liu Gang G
Molecular medicine (Cambridge, Mass.) 20120718
The uptake and clearance of apoptotic cells by macrophages and other phagocytic cells, a process called efferocytosis, is a major component in the resolution of inflammation. Increased concentrations of extracellular histones are found during acute inflammatory states and appear to contribute to organ system dysfunction and mortality. In these studies, we examined the potential role of histones in modulating efferocytosis. We found that phagocytosis of apoptotic neutrophils or thymocytes by macr ...[more]