Ontology highlight
ABSTRACT:
SUBMITTER: Cheng SK
PROVIDER: S-EPMC340941 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
PLoS biology 20040217 2
Members of the EGF-CFC family play essential roles in embryonic development and have been implicated in tumorigenesis. The TGFbeta signals Nodal and Vg1/GDF1, but not Activin, require EGF-CFC coreceptors to activate Activin receptors. We report that the TGFbeta signaling antagonist Lefty also acts through an EGF-CFC-dependent mechanism. Lefty inhibits Nodal and Vg1 signaling, but not Activin signaling. Lefty genetically interacts with EGF-CFC proteins and competes with Nodal for binding to these ...[more]