Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice.
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ABSTRACT:
SUBMITTER: Bolasco G
PROVIDER: S-EPMC3409677 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice.
Bolasco Giulia G Calogero Raffaele R Carrara Matteo M Banchaabouchi Mumna Al MA Bilbao Daniel D Mazzoccoli Gianluigi G Vinciguerra Manlio M
Aging 20120601 6
Locally acting insulin growth factor isoform (mIGF-1) and the NAD+-dependent protein deacetylase SIRT1 are implicated in life and health span. Heart failure is associated with aging and is a major cause of death. mIGF-1 protects the heart from oxidative stresses via SIRT1. SIRT1 subcellular localization and its genomic regulation by mIGF-1 are unknown. We show here that SIRT1 is located in the nuclei of a significant fraction of cardiomyocytes. Using high throughput sequencing approaches in mIGF ...[more]
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