Ontology highlight
ABSTRACT:
SUBMITTER: Czarnota GJ
PROVIDER: S-EPMC3409730 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Czarnota Gregory J GJ Karshafian Raffi R Burns Peter N PN Wong Shun S Al Mahrouki Azza A Lee Justin W JW Caissie Amanda A Tran William W Kim Christina C Furukawa Melissa M Wong Emily E Giles Anoja A
Proceedings of the National Academy of Sciences of the United States of America 20120709 30
We have discovered that ultrasound-mediated microbubble vascular disruption can enhance tumor responses to radiation in vivo. We demonstrate this effect using a human PC3 prostate cancer xenograft model. Results indicate a synergistic effect in vivo with combined single treatments of ultrasound-stimulated microbubble vascular perturbation and radiation inducing an over 10-fold greater cell kill with combined treatments. We further demonstrate with experiments in vivo that induction of ceramide-r ...[more]