Ontology highlight
ABSTRACT:
SUBMITTER: Choy RW
PROVIDER: S-EPMC3409748 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Choy Regina Wai-Yan RW Cheng Zhiliang Z Schekman Randy R
Proceedings of the National Academy of Sciences of the United States of America 20120618 30
Amyloid precursor protein (APP) is processed sequentially by the β-site APP cleaving enzyme and γ-secretase to generate amyloid β (Aβ) peptides, one of the hallmarks of Alzheimer's disease. The intracellular location of Aβ production-endosomes or the trans-Golgi network (TGN)-remains uncertain. We investigated the role of different postendocytic trafficking events in Aβ(40) production using an RNAi approach. Depletion of Hrs and Tsg101, acting early in the multivesicular body pathway, retained A ...[more]