Ontology highlight
ABSTRACT:
SUBMITTER: Meehan BM
PROVIDER: S-EPMC3409759 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Meehan Brian M BM Baughn Anthony D AD Gallegos Rene R Malamy Michael H MH
Proceedings of the National Academy of Sciences of the United States of America 20120709 30
Bacteroides fragilis can replicate in atmospheres containing ≤0.05% oxygen, but higher concentrations arrest growth by an unknown mechanism. Here we show that inactivation of a single gene, oxe (i.e., oxygen enabled) in B. fragilis allows for growth in concentrations as high as 2% oxygen while increasing the tolerance of this organism to room air. Known components of the oxidative stress response including the ahpC, kat, batA-E, and tpx genes were not individually important for microaerobic grow ...[more]