Dataset Information

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials.

ABSTRACT:

Introduction

Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess mortality among participants randomized to either vitamin D alone or vitamin D with calcium.

Subjects and methods

Through a systematic literature search, we identified 24 randomized controlled trials reporting data on mortality in which vitamin D was given either alone or with calcium. From a total of 13 trials with more than 1000 participants each, eight trials were included in our IPD analysis. Using a stratified Cox regression model, we calculated risk of death during 3 yr of treatment in an intention-to-treat analysis. Also, we performed a trial level meta-analysis including data from all studies.

Results

The IPD analysis yielded data on 70,528 randomized participants (86.8% females) with a median age of 70 (interquartile range, 62-77) yr. Vitamin D with or without calcium reduced mortality by 7% [hazard ratio, 0.93; 95% confidence interval (CI), 0.88-0.99]. However, vitamin D alone did not affect mortality, but risk of death was reduced if vitamin D was given with calcium (hazard ratio, 0.91; 95% CI, 0.84-0.98). The number needed to treat with vitamin D plus calcium for 3 yr to prevent one death was 151. Trial level meta-analysis (24 trials with 88,097 participants) showed similar results, i.e. mortality was reduced with vitamin D plus calcium (odds ratio, 0.94; 95% CI, 0.88-0.99), but not with vitamin D alone (odds ratio, 0.98; 95% CI, 0.91-1.06).

Conclusion

Vitamin D with calcium reduces mortality in the elderly, whereas available data do not support an effect of vitamin D alone.

SUBMITTER: Rejnmark L

PROVIDER: S-EPMC3410276 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Publications

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials.

Rejnmark Lars L Avenell Alison A Masud Tahir T Anderson Frazer F Meyer Haakon E HE Sanders Kerrie M KM Salovaara Kari K Cooper Cyrus C Smith Helen E HE Jacobs Elizabeth T ET Torgerson David D Jackson Rebecca D RD Manson JoAnn E JE Brixen Kim K Mosekilde Leif L Robbins John A JA Francis Roger M RM Abrahamsen Bo B

The Journal of clinical endocrinology and metabolism 20120517 8

<h4>Introduction</h4>Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess mortality among participants randomized to either vitamin D alone or vitamin D with calcium.<h4>Subjects and methods</h4>Through a systematic literature search, we identified 24 randomized controlled trials reporting data on mortality in which vit ...[more]

PMID: 22605432

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Dataset Information

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials.

Introduction

Subjects and methods

Results

Conclusion

Publications

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials.

Similar Datasets

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