Ontology highlight
ABSTRACT:
SUBMITTER: Orozco D
PROVIDER: S-EPMC3410390 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
EMBO reports 20120619 8
A subset of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) patients present pathological redistribution and aggregation of the nuclear protein fused in sarcoma (FUS) in the cytoplasm. Although FUS associates with the spliceosomal complex, no endogenous neuronal splicing targets have been identified. Here we identify Tau mRNA as a physiological splicing target of FUS. In mouse brain, FUS directly binds to Tau pre-mRNA, and knockdown of FUS in hippocampal neurons ...[more]