Ontology highlight
ABSTRACT:
SUBMITTER: Sandilands E
PROVIDER: S-EPMC3410392 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
EMBO reports 20120626 8
We have recently described that autophagic targeting of Src maintains cancer cell viability when FAK signalling is defective. Here, we show that the Ret tyrosine kinase is also degraded by autophagy in cancer cells with altered/reduced FAK signalling, preventing its binding to FAK at integrin adhesions. Inhibition of autophagy restores Ret localization to focal adhesions. Importantly, Src kinase activity is required to target Ret to autophagosomes and enhance Ret degradation. Src is thus a gener ...[more]