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Facile Synthesis of Clickable, Water-soluble and Degradable Polyphosphoesters.

ABSTRACT: "Click" chemistry is a library of efficient and reliable reactions, which have been used to functionalize various classes of bio- and synthetic macromolecular systems for the incorporation of designed properties and functions. In this report, azide-alkyne Huisgen cycloaddition and thiol-yne reactions, two classical "click" chemistries, were employed to functionalize biodegradable, clickable polyphosphoester homopolymers and their water-soluble copolymers. A stable alkyne-functionalized phospholane monomer was synthesized, its organocatalyzed polymerization kinetics were evaluated, and the resulting (co)polymers were utilized to develop this facile method that provides the synthesis of clickable, water-soluble and degradable polyphosphoesters, which can be adapted for various applications.

SUBMITTER: Zhang S

PROVIDER: S-EPMC3410554 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Facile Synthesis of Clickable, Water-soluble and Degradable Polyphosphoesters.

Zhang Shiyi S Li Ang A Zou Jiong J Lin Lily Yun LY Wooley Karen L KL

ACS macro letters 20120203 2

"Click" chemistry is a library of efficient and reliable reactions, which have been used to functionalize various classes of bio- and synthetic macromolecular systems for the incorporation of designed properties and functions. In this report, azide-alkyne Huisgen cycloaddition and thiol-yne reactions, two classical "click" chemistries, were employed to functionalize biodegradable, clickable polyphosphoester homopolymers and their water-soluble copolymers. A stable alkyne-functionalized phosphola ...[more]

PMID: 22866244

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