Androgen receptor as a targeted therapy for breast cancer.
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ABSTRACT:
SUBMITTER: Garay JP
PROVIDER: S-EPMC3410582 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Androgen receptor as a targeted therapy for breast cancer.
Garay Joseph P JP Park Ben H BH
American journal of cancer research 20120628 4
Breast cancer occurs at a high frequency in women and, given this fact, a primary focus of breast cancer research has been the study of estrogen receptor α (ER) signaling. However, androgens are known to play a role in normal breast physiology and therefore androgen receptor (AR) signaling is becoming increasingly recognized as an important contributor towards breast carcinogenesis. Moreover, the high frequency of AR expression in breast cancer makes it an attractive therapeutic target, but the ...[more]
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