Ontology highlight
ABSTRACT:
SUBMITTER: Ortega B
PROVIDER: S-EPMC3411023 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Ortega Bernardo B Mason Amanda K AK Welling Paul A PA
The Journal of biological chemistry 20120618 32
Select plasma membrane proteins can be marked as cargo for inclusion into clathrin-coated pits by common internalization signals (e.g. YXXΦ, dileucine motifs, NPXY) that serve as universal recognition sites for the AP-2 adaptor complex or other clathrin-associated sorting proteins. However, some surface proteins, such as the Kir2.3 potassium channel, lack canonical signals but are still targeted for clathrin-dependent endocytosis. Here, we explore the mechanism. We found an unusual endocytic sig ...[more]