Ontology highlight
ABSTRACT:
SUBMITTER: Seddon GM
PROVIDER: S-EPMC3411109 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Seddon Gavin M GM Bywater Robert P RP
Open biology 20120701 7
The year 2011 marked the half-centenary of the publication of what came to be known as the Anfinsen postulate, that the tertiary structure of a folded protein is prescribed fully by the sequence of its constituent amino acid residues. This postulate has become established as a credo, and, indeed, no contradictions seem to have been found to date. However, the experiments that led to this postulate were conducted on only a single protein, bovine ribonuclease A (RNAse). We conduct molecular dynami ...[more]