Ontology highlight
ABSTRACT:
SUBMITTER: Steckel M
PROVIDER: S-EPMC3411175 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Steckel Michael M Molina-Arcas Miriam M Weigelt Britta B Marani Michaela M Warne Patricia H PH Kuznetsov Hanna H Kelly Gavin G Saunders Becky B Howell Michael M Downward Julian J Hancock David C DC
Cell research 20120522 8
Oncogenic mutations in RAS genes are very common in human cancer, resulting in cells with well-characterized selective advantages, but also less well-understood vulnerabilities. We have carried out a large-scale loss-of-function screen to identify genes that are required by KRAS-transformed colon cancer cells, but not by derivatives lacking this oncogene. Top-scoring genes were then tested in a larger panel of KRAS mutant and wild-type cancer cells. Cancer cells expressing oncogenic KRAS were fo ...[more]