Ontology highlight
ABSTRACT:
SUBMITTER: Ross NC
PROVIDER: S-EPMC3411353 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Ross Nicolette C NC Kulkarni Santosh S SS McLaughlin Jay P JP Aldrich Jane V JV
Tetrahedron letters 20100901 38
The tryptophan isomers of the cyclic tetrapeptide CJ-15,208, reported to be a kappa opioid receptor (KOR) antagonist [Saito, T.; Hirai, H.; Kim, Y. J.; Kojima, Y.; Matsunaga, Y.; Nishida, H.; Sakakibara, T.; Suga, O.; Sujaku, T.; Kojima, N. J. Antibiot. (Tokyo)2002, 55, 847-854.], were synthesized to determine the tryptophan stereochemistry in the natural product. A strategy was developed to select linear precursor peptides that favor cyclization using molecular modeling, and optimized cyclizati ...[more]