Ontology highlight
ABSTRACT:
SUBMITTER: Smith KM
PROVIDER: S-EPMC3411895 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Smith Kristen M KM Guerau-de-Arellano Mireia M Costinean Stefan S Williams Jessica L JL Bottoni Arianna A Mavrikis Cox Gina G Satoskar Abhay R AR Croce Carlo M CM Racke Michael K MK Lovett-Racke Amy E AE Whitacre Caroline C CC
Journal of immunology (Baltimore, Md. : 1950) 20120706 4
Th cell programming and function is tightly regulated by complex biological networks to prevent excessive inflammatory responses and autoimmune disease. The importance of microRNAs (miRNAs) in this process is highlighted by the preferential Th1 polarization of Dicer-deficient T cells that lack miRNAs. Using genetic knockouts, we demonstrate that loss of endogenous miR-29, derived from the miR-29ab1 genomic cluster, results in unrestrained T-bet expression and IFN-γ production. miR-29b regulates ...[more]