Corticostriatal functional connectivity predicts transition to chronic back pain.
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ABSTRACT:
SUBMITTER: Baliki MN
PROVIDER: S-EPMC3411898 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
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Corticostriatal functional connectivity predicts transition to chronic back pain.
Baliki Marwan N MN Petre Bogdan B Torbey Souraya S Herrmann Kristina M KM Huang Lejian L Schnitzer Thomas J TJ Fields Howard L HL Apkarian A Vania AV
Nature neuroscience 20120701 8
The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition fro ...[more]
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