Ontology highlight
ABSTRACT:
SUBMITTER: Srinivasan G
PROVIDER: S-EPMC3411903 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Srinivasan Gayathri G Aitken Jesse D JD Zhang Benyue B Carvalho Frederic A FA Chassaing Benoit B Shashidharamurthy Rangaiah R Borregaard Niels N Jones Dean P DP Gewirtz Andrew T AT Vijay-Kumar Matam M
Journal of immunology (Baltimore, Md. : 1950) 20120711 4
Various states of inflammation, including sepsis, are associated with hypoferremia, which limits iron availability to pathogens and reduces iron-mediated oxidative stress. Lipocalin 2 (Lcn2; siderocalin, 24p3) plays a central role in iron transport. Accordingly, Lcn2-deficient (Lcn2KO) mice exhibit elevated intracellular labile iron. In this study, we report that LPS induced systemic Lcn2 by 150-fold in wild-type mice at 24 h. Relative to wild-type littermates, Lcn2KO mice were markedly more sen ...[more]