Ontology highlight
ABSTRACT:
SUBMITTER: Gopalakrishnan J
PROVIDER: S-EPMC3411905 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Gopalakrishnan Jayachandran J Chim Yiu-Cheung Frederick YC Ha Andrew A Basiri Marcus L ML Lerit Dorothy A DA Rusan Nasser M NM Avidor-Reiss Tomer T
Nature cell biology 20120624 8
Regulated centrosome biogenesis is required for accurate cell division and for maintaining genome integrity. Centrosomes consist of a centriole pair surrounded by a protein network known as pericentriolar material (PCM). PCM assembly is a tightly regulated, critical step that determines the size and capability of centrosomes. Here, we report a role for tubulin in regulating PCM recruitment through the conserved centrosomal protein Sas-4. Tubulin directly binds to Sas-4; together they are compone ...[more]