Ontology highlight
ABSTRACT:
SUBMITTER: Morecroft I
PROVIDER: S-EPMC3412483 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Morecroft Ian I White Katie K Caruso Paola P Nilsen Margaret M Loughlin Lynn L Alba Raul R Reynolds Paul N PN Danilov Sergei M SM Baker Andrew H AH Maclean Margaret R MR
Molecular therapy : the journal of the American Society of Gene Therapy 20120424 8
Serotonin is produced by pulmonary arterial endothelial cells (PAEC) via tryptophan hydroxylase-1 (Tph1). Pathologically, serotonin acts on underlying pulmonary arterial cells, contributing to vascular remodeling associated with pulmonary arterial hypertension (PAH). The effects of hypoxia on PAEC-Tph1 activity are unknown. We investigated the potential of a gene therapy approach to PAH using selective inhibition of PAEC-Tph1 in vivo in a hypoxic model of PAH. We exposed cultured bovine pulmonar ...[more]