Ontology highlight
ABSTRACT:
SUBMITTER: Robinson G
PROVIDER: S-EPMC3412905 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Robinson Giles G Parker Matthew M Kranenburg Tanya A TA Lu Charles C Chen Xiang X Ding Li L Phoenix Timothy N TN Hedlund Erin E Wei Lei L Zhu Xiaoyan X Chalhoub Nader N Baker Suzanne J SJ Huether Robert R Kriwacki Richard R Curley Natasha N Thiruvenkatam Radhika R Wang Jianmin J Wu Gang G Rusch Michael M Hong Xin X Becksfort Jared J Gupta Pankaj P Ma Jing J Easton John J Vadodaria Bhavin B Onar-Thomas Arzu A Lin Tong T Li Shaoyi S Pounds Stanley S Paugh Steven S Zhao David D Kawauchi Daisuke D Roussel Martine F MF Finkelstein David D Ellison David W DW Lau Ching C CC Bouffet Eric E Hassall Tim T Gururangan Sridharan S Cohn Richard R Fulton Robert S RS Fulton Lucinda L LL Dooling David J DJ Ochoa Kerri K Gajjar Amar A Mardis Elaine R ER Wilson Richard K RK Downing James R JR Zhang Jinghui J Gilbertson Richard J RJ
Nature 20120801 7409
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of 37 tumours and matched normal blood. One-hundred and thirty-six genes harbouring somatic mutations in this discovery set were sequenced in an additional 56 medulloblastomas. Recurrent mutations were detected in 41 genes not yet implicated in medulloblastoma; several target distinct components of the epigenetic machine ...[more]