Ontology highlight
ABSTRACT:
SUBMITTER: Ribas J
PROVIDER: S-EPMC3413119 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Ribas Judit J Ni Xiaohua X Castanares Mark M Liu Minzhi M MM Esopi David D Yegnasubramanian Srinivasan S Rodriguez Ronald R Mendell Joshua T JT Lupold Shawn E SE
Nucleic acids research 20120413 14
miR-21 is the most commonly over-expressed microRNA (miRNA) in cancer and a proven oncogene. Hsa-miR-21 is located on chromosome 17q23.2, immediately downstream of the vacuole membrane protein-1 (VMP1) gene, also known as TMEM49. VMP1 transcripts initiate ∼ 130 kb upstream of miR-21, are spliced, and polyadenylated only a few hundred base pairs upstream of the miR-21 hairpin. On the other hand, primary miR-21 transcripts (pri-miR-21) originate within the last introns of VMP1, but bypass VMP1 pol ...[more]