Ontology highlight
ABSTRACT:
SUBMITTER: Stolzenburg S
PROVIDER: S-EPMC3413152 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Stolzenburg Sabine S Rots Marianne G MG Beltran Adriana S AS Rivenbark Ashley G AG Yuan Xinni X Qian Haili H Strahl Brian D BD Blancafort Pilar P
Nucleic acids research 20120504 14
The transcription factor (TF) SOX2 is essential for the maintenance of pluripotency and self-renewal in embryonic stem cells. In addition to its normal stem cell function, SOX2 over-expression is associated with cancer development. The ability to selectively target this and other oncogenic TFs in cells, however, remains a significant challenge due to the 'undruggable' characteristics of these molecules. Here, we employ a zinc finger (ZF)-based artificial TF (ATF) approach to selectively suppress ...[more]